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According to a 2022 study, сompounded tirzepatide injections can start working within hours after your first dose, reaching the most concentrated levels in your system anywhere between 8 and 72 hours, and many patients begin experiencing weight loss within a couple of weeks
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It says the majority of that early drop represents water and glycogen rather than adipose tissue, and lists four contributors: reduced caloric intake from appetite suppression, decreased water retention as insulin levels normalize, slowed gastric emptying, and minor glycogen depletion
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